Isoxazolines and isoxazoles as factor Xa inhibitors.


3,4,5-Trisubstituted isoxazolines (2) and isoxazoles (3) were prepared and evaluated for their in vitro and in vivo antithrombotic efficacy. They were compared to 3,5,5-trisubstituted isoxazolines (1) for Factor Xa selectivity and potency. They were also compared in an arterio-venous (A-V) shunt model of thrombosis. 


Cite this paper

@article{Pruitt2000IsoxazolinesAI, title={Isoxazolines and isoxazoles as factor Xa inhibitors.}, author={James R Pruitt and Domenick J. Pinto and Mar{\'i}a Julia Estrella and Lori L Bostrom and Robert M. Knabb and Pancras C. Wong and Matthew R. Wright and Ruth R. Wexler}, journal={Bioorganic & medicinal chemistry letters}, year={2000}, volume={10 8}, pages={685-9} }