Isovaline, a rare amino acid, has anticonvulsant properties in two in vitro hippocampal seizure models by increasing interneuronal activity.

@article{Shin2011IsovalineAR,
  title={Isovaline, a rare amino acid, has anticonvulsant properties in two in vitro hippocampal seizure models by increasing interneuronal activity.},
  author={Damian Seung-ho Shin and Wilson Yu and Alex Sutton and Megan E Calos and Ernest Puil and Peter L. Carlen},
  journal={Epilepsia},
  year={2011},
  volume={52 11},
  pages={2084-93}
}
PURPOSE We investigated whether RS-isovaline, a unique amino acid found in carbonaceous meteorites and presumed extraterrestrial, has anticonvulsant properties in rat hippocampal slices in vitro. METHODS Extracellular recordings were obtained in the rat hippocampal CA1 pyramidal layer in two in vitro seizure models: perfusion of low (0.25 mm) Mg(2+) and… CONTINUE READING