Isotype distribution and clinical relevance of anti-beta2-glycoprotein I (beta2-GPI) antibodies: importance of IgA isotype.

@article{Lakos1999IsotypeDA,
  title={Isotype distribution and clinical relevance of anti-beta2-glycoprotein I (beta2-GPI) antibodies: importance of IgA isotype.},
  author={Gabriella Lakos and Emese Kiss and N Reg{\"e}czy and P. Tarjan and P{\'a}l Solt{\'e}sz and Margit Zeher and Edit Bodolay and S Szakony and S{\'a}ndor Sipka and Gyula Szegedi},
  journal={Clinical and experimental immunology},
  year={1999},
  volume={117 3},
  pages={574-9}
}
The aim of this study was to evaluate the prevalence of IgG, IgA and IgM anti-beta2-GPI antibodies in anti-phospholipid syndrome (APS), and to establish the clinical significance of IgA type antibodies compared with the other isotypes. Anti-beta2-GPI antibodies were measured in the sera of 70 patients by solid-phase enzyme immunoassay in gamma-irradiated polystyrene plates coated with human purified beta2-GPI. Thirty-three out of the 70 patients were classified as having APS: three of them had… CONTINUE READING

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