Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-κB and TLR/MAPK signaling in LPS-induced RAW264.7 cells.

@article{Li2017IsotrifoliolIP,
  title={Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-κB and TLR/MAPK signaling in LPS-induced RAW264.7 cells.},
  author={Hua Li and Jeong-Hyun Yoon and Hyo-Jun Won and Hyeon-Seon Ji and Heong Joo Yuk and Ki Hun Park and Ho-Yong Park and T S Jeong},
  journal={International immunopharmacology},
  year={2017},
  volume={45},
  pages={110-119}
}
Soybeans, produced by Glycine max (L.) Merr., contain high levels of isoflavones, such as genistein and daidzein. However, soy leaves contain more diverse and abundant flavonol glycosides and coumestans, as compared to the soybean. This study investigated the anti-inflammatory effects of the major coumestans present in soy leaf (coumestrol, isotrifoliol, and phaseol) in lipopolysaccharide (LPS)-induced RAW264.7 cells. Coumestans significantly reduced LPS-induced nitric oxide (NO), prostaglandin… CONTINUE READING