Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

@article{Radu2004IsotretinoinTI,
  title={Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.},
  author={Roxana A Radu and Nathan L. Mata and Steven Nusinowitz and Xinran N Liu and Gabriel H. Travis},
  journal={Novartis Foundation symposium},
  year={2004},
  volume={255},
  pages={51-63; discussion 63-7, 177-8}
}
Recessive Stargardt's macular degeneration is an inherited blinding disease of children caused by mutations in the ABCR gene. The primary pathologic defect in Stargardt's discase is accumulation of toxic lipofuscin pigments such as N-retinylidene-N-retinylethanolamine (A2E) in cells of the retinal pigment epithelium (RPE). This accumulation appears to be responsible for the photoreceptor death and severe visual loss in Stargardt's patients. Here, we tested a novel therapeutic strategy to… CONTINUE READING
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