Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.
@article{Chia2005IsotretinoinTA, title={Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.}, author={Christina Chia and Whitney C. Lane and John T. Chibnall and A L Allen and Elaine C Siegfried}, journal={Archives of dermatology}, year={2005}, volume={141 5}, pages={ 557-60 } }
OBJECTIVE
To determine whether patients with moderate to severe acne who were treated with isotretinoin experienced significant increases in depressive symptoms over a 3- to 4-month period compared with patients who received conservative acne therapy.
DESIGN
Cohort study.
SETTING
Hospital-affiliated and community-based clinics in St Louis, Mo.
PARTICIPANTS
One hundred thirty-two subjects aged 12 to 19 years with moderate to severe acne.
MAIN OUTCOME MEASURES
Depressive symptoms were…
96 Citations
Evaluation of depressive symptoms in acne patients treated with isotretinoin
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The results provide no relationship between isotretinoin use and depression in acne patients and Improvement in anxiety was detected later than the improvement in depressive symptoms and a statistically significant difference was detected between the first and the second follow-up.
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Changes of psychiatric parameters and their relationships by oral isotretinoin in acne patients
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Results indicate that oral isotretinoin therapy alleviates depressive symptoms and improvements in depression are directly related to acne‐related life quality improvements rather than to improvement in acne grade.
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An association of the use of isotretinoin in patients with acne with significantly improved depression symptoms is suggested, and future randomised controlled trials are needed to verify the present findings.
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Comparison of depression, anxiety and life quality in acne vulgaris patients who were treated with either isotretinoin or topical agents
- Medicine, PsychologyInternational journal of dermatology
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Patients with acne who were treated with isotretinoin experienced significant increases in psychiatric symptoms over a 4‐month period compared with patients who received topical acne therapy.
Does isotretinoin therapy of acne cure or cause depression?
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The epidemiological data, the underlying molecular pathogenesis, and the aspects of prevention concerning retinoid‐induced depression in acne from the practical point of view of a dermatologist are highlighted.
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