Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.

@article{Chia2005IsotretinoinTA,
  title={Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.},
  author={Christina Chia and Whitney C. Lane and John T. Chibnall and A L Allen and Elaine C Siegfried},
  journal={Archives of dermatology},
  year={2005},
  volume={141 5},
  pages={
          557-60
        }
}
OBJECTIVE To determine whether patients with moderate to severe acne who were treated with isotretinoin experienced significant increases in depressive symptoms over a 3- to 4-month period compared with patients who received conservative acne therapy. DESIGN Cohort study. SETTING Hospital-affiliated and community-based clinics in St Louis, Mo. PARTICIPANTS One hundred thirty-two subjects aged 12 to 19 years with moderate to severe acne. MAIN OUTCOME MEASURES Depressive symptoms were… 

Figures from this paper

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Patients with acne who were treated with isotretinoin experienced significant increases in psychiatric symptoms over a 4‐month period compared with patients who received topical acne therapy.

Does isotretinoin therapy of acne cure or cause depression?

The epidemiological data, the underlying molecular pathogenesis, and the aspects of prevention concerning retinoid‐induced depression in acne from the practical point of view of a dermatologist are highlighted.
...

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