Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.

  title={Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.},
  author={Christina Y. Chia and W. Lane and J. Chibnall and A. Allen and Elaine S. Siegfried},
  journal={Archives of dermatology},
  volume={141 5},
  • Christina Y. Chia, W. Lane, +2 authors Elaine S. Siegfried
  • Published 2005
  • Medicine
  • Archives of dermatology
  • OBJECTIVE To determine whether patients with moderate to severe acne who were treated with isotretinoin experienced significant increases in depressive symptoms over a 3- to 4-month period compared with patients who received conservative acne therapy. DESIGN Cohort study. SETTING Hospital-affiliated and community-based clinics in St Louis, Mo. PARTICIPANTS One hundred thirty-two subjects aged 12 to 19 years with moderate to severe acne. MAIN OUTCOME MEASURES Depressive symptoms were… CONTINUE READING
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