Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.

  title={Isotretinoin therapy and mood changes in adolescents with moderate to severe acne: a cohort study.},
  author={Christina Chia and Whitney C. Lane and John T. Chibnall and A L Allen and Elaine C Siegfried},
  journal={Archives of dermatology},
  volume={141 5},
OBJECTIVE To determine whether patients with moderate to severe acne who were treated with isotretinoin experienced significant increases in depressive symptoms over a 3- to 4-month period compared with patients who received conservative acne therapy. DESIGN Cohort study. SETTING Hospital-affiliated and community-based clinics in St Louis, Mo. PARTICIPANTS One hundred thirty-two subjects aged 12 to 19 years with moderate to severe acne. MAIN OUTCOME MEASURES Depressive symptoms were… 

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Patients with acne who were treated with isotretinoin experienced significant increases in psychiatric symptoms over a 4‐month period compared with patients who received topical acne therapy.

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The epidemiological data, the underlying molecular pathogenesis, and the aspects of prevention concerning retinoid‐induced depression in acne from the practical point of view of a dermatologist are highlighted.



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Isotretinoin Use and Subsequent Depression and Suicide

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Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicide.

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Depression and suicidal ideation in dermatology patients with acne, alopecia areata, atopic dermatitis and psoriasis

  • GuptaGupta
  • Psychology, Medicine
    The British journal of dermatology
  • 1998
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Treatment of the depressed and dysmorphophobic acne patient

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