Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment.

@article{Layton1993IsotretinoinFA,
  title={Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment.},
  author={Alison Layton and H E Knaggs and Jeffrey P. Taylor and William James Cunliffe},
  journal={The British journal of dermatology},
  year={1993},
  volume={129 3},
  pages={292-6}
}
The purpose of this study was to assess the long-term benefit of isotretinoin in otherwise therapy-resistant acne. We also assessed risk factors which might influence the long-term outcome. We studied 88 patients (mean age 20.8 years), most of whom had suffered from acne for many years (mean 7.4 years). They received isotretinoin in an initial dose of 0.5 or 1.0 mg/kg/day. The dose was subsequently adjusted according to response and side-effects. Most patients only required 4 months' therapy to… CONTINUE READING

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