Isotretinoin and mental health in adolescents: Australian consensus

  title={Isotretinoin and mental health in adolescents: Australian consensus},
  author={Casey J Rowe and Lynda Spelman and Margaret Oziemski and Alexander Edwin Christopher Ryan and Shobhan Manoharan and Perry Wilson and Michael Daubney and James Scott},
  journal={Australasian Journal of Dermatology},
Acne is a common condition among adolescents and has the potential to negatively impact on the psychological well‐being of those who suffer from it. In particular, depression and suicidal ideation are more common in adolescents with acne. Successful treatment of acne can improve the quality of life and reduce levels of anxiety and depression in these individuals. The current treatment of choice for severe or refractive acne is isotretinoin, a retinoid. While the possible causal association… 

Isotretinoin: Communication for Preventing Birth Defects and Alerting of an Uncertain Risk of Suicide

This chapter discusses the succession of pregnancy prevention programmes (PPPs) for isotretinoin, a medicine effective against acne, but with high risks for birth defects and developmental disorders


This review article evaluates the published articles about the psychiatric side-effects of isotretinoin and discusses the psychopathologic effects of isot retinoin.

Isotretinoin is key in treating acne vulgaris

Monitoring of depressed patients’ mental state, rather than withholding isotretinoin, is the recommended approach, because it is teratogenic and pregnancy must be prevented.

Isotretinoin was not associated with depression or anxiety: A twelve-week study.

This study confirms the safety of ITT regarding psychological side effects in regular dermatological patients and indicatesceptible subjects may exist but their identification requires additional strategies.

Optimizing Isotretinoin Treatment of Acne: Update on Current Recommendations for Monitoring, Dosing, Safety, Adverse Effects, Compliance, and Outcomes

  • M. Landis
  • Medicine
    American Journal of Clinical Dermatology
  • 2020
The article outlines the advantages and disadvantages of standard, high-dose, and low-dose isotretinoin regimens; discusses the current status of controversies surrounding isot retinoin (including depression/suicide, pregnancy, and inflammatory bowel disease); reviews monitoring recommendations and treatment for hypertriglyceridemia and elevated transaminase levels; and discusses common adverse effects seen with isotretin, along with their treatment and prevention.

Actualización en psicodermatología

It is important to increase research and interest in this important issue, as an integrative and multidisciplinary approach allows for interventions in the vicious circle between psychiatric dysfunction and skin symptoms, improving significantly the quality of life of patients.

Suicidal risk with isotretinoin treatment – a never‐ending story

  • U. GielerT. Gieler
  • Medicine, Psychology
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2020
A recently large population-based study by Droitcourt et al. (7/8) in this journal gives new evidence for answering the important question about isotretinoin treatment and suicidal attempts.

Cutaneous Manifestations of Psychiatric Disorders and Management

This chapter will focus on those psychiatric conditions that have skin findings, and may present to a dermatologists’ office for diagnosis and treatment.

Long-term effect of systemic isotretinoin on female fertility

The deteriorative effects of systemic isotretinoin treatment on ovarian reserve, which can be accepted as an indicator of female fertility, diminish in time.

Isotretinoin and affective disorders: thirty years later.

The interaction between acne vulgaris and the psyche.

The scope of the problem is highlighted, at-risk patients are identified, and dermatologists assist patients with both their acne and their psychologic response to it are identified.

Psychosocial Effects of Acne

  • D. R. Thomas
  • Medicine, Psychology
    Journal of cutaneous medicine and surgery
  • 2004
It is shown that acne has significant effect on self-image and impacts quality of life and acne severity grading should incorporate life quality scores to better establish the true impact of this condition on patients in order to optimize therapy.

The Psychosocial Effects of Acne on Adolescents

  • Daniel P. KrowchukT. StancinRosemary KeskinenR. WalkerJ. BassTrina M. Anglin
  • Medicine, Psychology
    Pediatric dermatology
  • 1991
It is demonstrated that acne is perceived by adolescents to have important negative personal and social consequences, and that improvement in these areas may accompany medical treatment.

Functional brain imaging alterations in acne patients treated with isotretinoin.

This study suggests that isotretinoin treatment is associated with changes in brain functioning, a brain area known to mediate symptoms of depression.

The Psychological Correlates of Treatment Efficacy in Acne

It is demonstrated that the psychological profile exhibited by acne patients pretreatment may be largely reversed over treatment time, and that this psychological improvement is generally maintained at follow-up assessment.

An update on the presence of psychiatric comorbidities in acne patients, part 1: overview of prevalence.

The rates of general psychologic comorbidity, depression, anxiety, and BDD are reviewed in patients with Acne vulgaris.

Retinoic acid and affective disorders: the evidence for an association.

The literature reviewed is consistent with associations of isotretinoin administration with depression and with suicide in a subgroup of vulnerable individuals, and may have implications for a greater understanding of the neurobiology of affective disorders.

Management of acne: a report from a Global Alliance to Improve Outcomes in Acne.