Isotretinoin and fenofibrate induce adiposity with distinct effect on metabolic profile in a rat model of the insulin resistance syndrome


OBJECTIVE: To investigate the effect of transcription-modulating drugs, fenofibrate and isotretinoin, on metabolic profile, insulin sensitivity of adipose and muscle tissues and gene expression in a genetic model of insulin resistance syndrome, polydactylous rat strain (PD/Cub).DESIGN: Administration of fenofibrate (100 mg/kg/day), isotretinoin (30 mg/kg… (More)
DOI: 10.1038/sj.ijo.0802613


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