Isotretinoin-Induced Inflammatory Bowel Disease in an Adolescent

  title={Isotretinoin-Induced Inflammatory Bowel Disease in an Adolescent},
  author={Denise Reniers and John McLaren Howard},
  journal={Annals of Pharmacotherapy},
  pages={1214 - 1216}
OBJECTIVE: To report a case of inflammatory bowel disease (IBD) associated with use of isotretinoin. CASE SUMMARY: A 17-year-old boy presented with new-onset rectal bleeding after completion of a five-month course of isotretinoin. A diagnosis of ulcerative colitis was made. His condition worsened despite therapy with 5-aminosalicylic acid, steroid retention enema, iron supplement, and prednisone. Five months after the onset of rectal bleeding, he had lost 11.4 kg and developed bilateral pitting… 
Isotretinoin-Associated Crohn's Disease-Like Ileo-Colitis in a Renal Transplanted Patient: Case Report
The case report of first renal transplanted and immune suppressed case in English literature who developed Crohn's disease-like ileocolitis following the use of isotretinoin is presented.
Isotretinoin-induced inflammatory bowel disease.
Three case reports on inflammatory bowel disease associated with use of isotretinoin are described and it is appealed to the readers for a reaction to this, to shed more light on the likeliness of this alleged association.
Ulcerative colitis and isotretinoin: Is there a causal relationship?
We are reporting the case of a 39-year-old woman without toxic habits and with a history of mild mitral valve prolapsed that, after treatment of acne with dermatologist prescribed isotretinoin,
Isotretinoin and intestinal inflammation: what gastroenterologists need to know
The literature on the association of isotretinoin therapy with intestinal inflammation and IBD is discussed, an update of epidemiological and pharmaco-vigilance data is presented, and possible underlying mechanisms are highlighted, based upon recent advances in mucosal immunology.
Isotretinoin-associated pan-enteritis.
A 22-year-old man has been recently admitted to the authors' Department with a 10-day history of melena and underwent video capsule endoscopy that showed a diffuse and extensive intestinal inflammation with multiple linear, irregular-shaped jejunal ulcerations, and apthae.
Isotretinoin exposure and risk of inflammatory bowel disease.
This study did not show an increased risk of IBD with prior isotretinoin use, and the risk seemed to be decreased, suggesting the anti-inflammatory and immune-modulating effects of isot retinoin may be worth exploring.
Possible Association Between Isotretinoin and Inflammatory Bowel Disease
In a subgroup of patients, isotretinoin might serve as a trigger for IBD, and strength of causality was determined using the Naranjo adverse drug reaction (ADR) probability scale.
Isotretinoin Is Not Associated With Inflammatory Bowel Disease: A Population-Based Case–Control Study
The data suggest that isotretinoin is not likely to cause chronic IBD, and patients with IBD were no more likely to have used isot retinoin before diagnosis than were sex-, age-, and geography-matched controls.
Does exposure to isotretinoin increase the risk for the development of inflammatory bowel disease? A meta-analysis
Isotretinoin exposure is not associated with an increased risk of developing both ulcerative colitis and Crohn’s disease.
bowel disease with isotretinoin
A27-year-old female medical student experienced an episode of intermittent bloody diarrhoea for6 weeks and decided against starting treatment, but six months later, she started a 16-week course of isotretinoin 40 mg daily for acne vulgaris.


Treatment of severe acne with isotretinoin in patients with inflammatory bowel disease
Four patients with inflammatory bowel disease and severe cystic acne were treated with isotretinoin and one patient had two episodes of profuse rectal bleeding that were probably related to pre‐existing haemorrhoids.
Treatment of pyoderma faciale with isotretinoin in a patient with ulcerative colitis.
Despite concern about the potential adverse effects of systemic retinoids on underlying inflammatory bowel disease, isotretinoin was given to a patient with refractory pyoderma faciale and response was dramatic, and no ill effects were encountered.
More than a gut reaction: Extraintestinal complications of IBD
Crohn disease and ulcerative colitis are not confined to the gastrointestinal tract, and growth failure, painful joints, and oral or skin lesions are just a few of the nonintestinal signs and symptoms that can help make a diagnosis.
Remission of hyperthyroidims and oral contraceptive therapy. [Answer to question].
There is no endocrine contraindication to the use of oral contraceptives (OCs) in a 31-year-old nulliparous woman who presumably is in remission from hyperthyroidism. Yet several important
Inflammatory bowel disease in pediatric and adolescent patients.
A method for estimating the probability of adverse drug reactions
It was shown that the ADR probability scale has consensual, content, and concurrent validity and may be applicable to postmarketing drug surveillance.
Oral isotretinoin and inflammatory bowel disease.
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    Journal of the American Academy of Dermatology
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