Isotopic effect study of propofol deuteration on the metabolism, activity, and toxicity of the anesthetic.

Abstract

The use of isotopic substitution to delay the oxidative metabolism of the anesthetic propofol 1 was studied. The aromatic hydrogens of propofol 1 were replaced by deuterium to produce the mono- and trideuterated derivatives 4 and 5. In vitro metabolic studies on human hepatic microsomes showed no isotopic effect in the para hydroxylation of propofol, and 1… (More)

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@article{Helfenbein2002IsotopicES, title={Isotopic effect study of propofol deuteration on the metabolism, activity, and toxicity of the anesthetic.}, author={Julie Helfenbein and Claire Lartigue and Elisabeth Noirault and Ekram M Azim and J Legailliard and M. J. Galmier and J. C. Madelmont}, journal={Journal of medicinal chemistry}, year={2002}, volume={45 26}, pages={5806-8} }