Isotope studies in gastric emptying


that the frequency of salivary isoamylase elevation is quite similar. We believe that the high incidence of hyperamylasemia in alcoholic patients (39%) in our study is most likely related to the different study design and patient selection and not to the statistical treatment of the results. The upper limit of total serum amylase activity determination is based on a mean plus 2 standard deviations of serum amylase activity in 100 normal subjects screened in our laboratory. Furthermore, isoamylase determination by the isoelectric focusing method is a precise, although very tedious, method. For that reason we have been able to study a limited but sizable number of blood samples obtained from normal persons for isoamylase determination. To minimize the element of uncertainty associated with the use of only a limited number of control observations, we have defined a significant elevation of a specific isoamylase as a value which is more than mean + 2 SD (95% probability) of control observations. In several previous studies, an isoamylase value which falis above the mean + 1 so has been labeled as a significant elevation. It is interesting to note that Di'. Berk and coworkers did not define the criteria for determining the "significant" salivary or pancreatic isoamylase elevation in their published report. SUDHIR K. DUTTA, MD University of Maryland School of Medicine Baltimore VA Medical Center Baltimore, Maryland

DOI: 10.1007/BF01296742

Cite this paper

@article{Jobin1982IsotopeSI, title={Isotope studies in gastric emptying}, author={Gilles Jobin and Raymond Jian and John Garry Moore and Paul E. Christian}, journal={Digestive Diseases and Sciences}, year={1982}, volume={27}, pages={571-572} }