Isotope ratio monitoring of small molecules and macromolecules by liquid chromatography coupled to isotope ratio mass spectrometry.

@article{Godin2005IsotopeRM,
  title={Isotope ratio monitoring of small molecules and macromolecules by liquid chromatography coupled to isotope ratio mass spectrometry.},
  author={J Godin and J{\"o}rg Hau and L P Fay and G{\'e}rard Hopfgartner},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2005},
  volume={19 18},
  pages={2689-98}
}
In the field of isotope ratio mass spectrometry, the introduction of an interface allowing the connection of liquid chromatography (LC) and isotope ratio mass spectrometry (IRMS) has opened a range of new perspectives. The LC interface is based on a chemical oxidation, producing CO2 from organic molecules. While first results were obtained from the analysis of low molecular weight compounds, the application of compound-specific isotope analysis by irm-LC/MS to other molecules, in particular… CONTINUE READING
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