Isotope-dilution liquid chromatography-tandem mass spectrometry candidate reference method for total testosterone in human serum.

@article{Botelho2013IsotopedilutionLC,
  title={Isotope-dilution liquid chromatography-tandem mass spectrometry candidate reference method for total testosterone in human serum.},
  author={Julianne Cook Botelho and Christopher Shacklady and Hans C Cooper and Susan S-C Tai and Katleen Van Uytfanghe and Linda M. Thienpont and Hubert W. Vesper},
  journal={Clinical chemistry},
  year={2013},
  volume={59 2},
  pages={372-80}
}
BACKGROUND We developed and evaluated a candidate reference measurement procedure (RMP) to standardize testosterone measurements, provide highly accurate and precise value assignments for the CDC Hormone Standardization Program, and ensure accurate and comparable results across testing systems and laboratories. METHODS After 2 liquid/liquid extractions of serum with a combination of ethyl acetate and hexane, we quantified testosterone by isotope-dilution liquid chromatography-tandem mass… CONTINUE READING
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