Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells

@article{Mukherjee2009IsothiocyanatesST,
  title={Isothiocyanates sensitize the effect of chemotherapeutic drugs via modulation of protein kinase C and telomerase in cervical cancer cells},
  author={Sutapa Mukherjee and Shubhabrata Dey and Rathindra Kumar Bhattacharya and Madhumita Roy},
  journal={Molecular and Cellular Biochemistry},
  year={2009},
  volume={330},
  pages={9-22}
}
Isothiocyanates have potential chemopreventive and antitumor effects. In the present study, we examined the actions of PEITC and sulphoraphane in modulating the activity of protein kinase C (PKC) and telomerase in cervical cancer cell line HeLa. These tumor markers are highly activated in human cancers. These compound efficiently downregulated the antiapoptotic isoforms (PKC-α, -βII, -ε, and -ζ) as well as telomerase, whereas the proapoptotic form (PKC-δ) was upregulated. Studies were performed… CONTINUE READING

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Exploring the effects of isothiocyanates on chemotherapeutic drugs.

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