Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury

@inproceedings{Toyama2011IsothiocyanatesRM,
  title={Isothiocyanates Reduce Mercury Accumulation via an Nrf2-Dependent Mechanism during Exposure of Mice to Methylmercury},
  author={Takashi Toyama and Yasuhiro Shinkai and Akira Yasutake and Koji Uchida and Masayuki Yamamoto and Yoshito Kumagai},
  booktitle={Environmental health perspectives},
  year={2011}
}
BACKGROUND Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg. OBJECTIVES We investigated the protective effect of isothiocyanates, which are known to activate Nrf2, on the accumulation of mercury after exposure to MeHg in vitro and in vivo. METHODS We used primary mouse hepatocytes in in vitro experiments and mice as… CONTINUE READING
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