Isothermal self-assembly of complex DNA structures under diverse and biocompatible conditions.

@article{Myhrvold2013IsothermalSO,
  title={Isothermal self-assembly of complex DNA structures under diverse and biocompatible conditions.},
  author={Cameron Myhrvold and Mingjie Dai and Pamela A. Silver and Peng Yin},
  journal={Nano letters},
  year={2013},
  volume={13 9},
  pages={
          4242-8
        }
}
Nucleic acid nanotechnology has enabled researchers to construct a wide range of multidimensional structures in vitro. Until recently, most DNA-based structures were assembled by thermal annealing using high magnesium concentrations and nonphysiological environments. Here, we describe a DNA self-assembly system that can be tuned to form a complex target structure isothermally at any prescribed temperature or homogeneous condition within a wide range. We were able to achieve isothermal assembly… CONTINUE READING
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