Isothermal multiple displacement amplification: a highly reliable approach for generating unlimited high molecular weight genomic DNA from clinical specimens.

@article{Luthra2004IsothermalMD,
  title={Isothermal multiple displacement amplification: a highly reliable approach for generating unlimited high molecular weight genomic DNA from clinical specimens.},
  author={Rajyalakshmi Luthra and L Jeffrey Medeiros},
  journal={The Journal of molecular diagnostics : JMD},
  year={2004},
  volume={6 3},
  pages={236-42}
}
Isothermal multiple strand displacement amplification (IMDA) of the whole human genome is a promising method for procuring abundant DNA from valuable and often limited clinical specimens. However, whether DNA generated by this method is of high quality and a faithful replication of the DNA in the original specimen, allowing for subsequent molecular diagnostic testing, requires verification. In this study, we evaluated the suitability of IMDA-generated DNA (IMDA-DNA) for detecting antigen… CONTINUE READING
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