Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors.

@article{Franchetti1998IsostericAO,
  title={Isosteric analogues of nicotinamide adenine dinucleotide derived from furanfurin, thiophenfurin, and selenophenfurin as mammalian inosine monophosphate dehydrogenase (type I and II) inhibitors.},
  author={Palmarisa Franchetti and Loredana Cappellacci and Paolo Perlini and Hiremagalur N. Jayaram and Andrew Avigdor Butler and Bryan P. Schneider and Frank R. Collart and Eliezer Huberman and Mario Grifantini},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 10},
  pages={
          1702-7
        }
}
Dinucleotides TFAD (6), FFAD (7), and SFAD (8), isosteric NAD analogues derived, respectively, from C-nucleosides 5-beta-d-ribofuranosylthiophene-3-carboxamide (thiophenfurin, 1), 5-beta-d-ribofuranosylfuran-3-carboxamide (furanfurin, 2), and 5-beta-d-ribofuranosylselenophene-3-carboxamide (selenophenfurin, 5), were synthesized as human inosine monophosphate dehydrogenase (IMPDH) type I and II inhibitors. The synthesis was carried out by imidazole-catalyzed coupling of the 5'-monophosphate of 1… Expand
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