Isosorbide 5-mononitrate pharmacokinetics.

  title={Isosorbide 5-mononitrate pharmacokinetics.},
  author={Leslie F Chasseaud},
  volume={74 Suppl 1},
Isosorbide 5-mononitrate differs from other clinically used organic nitrate vasodilators because of its almost complete oral absorption, the low intersubject variability in its plasma concentrations and pharmacokinetic parameters, its relatively long half-life and its lack of active metabolites. The drug does not appear to be bound to plasma proteins and it is metabolized primarily by denitration and conjugation. Its clearance is 127 ml/min, volume of distribution 48.5 litres and half-life 4.4… CONTINUE READING

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