Isoserine-based biotinylated photoaffinity probes that interact with penicillin-binding protein 1b.

Abstract

The photolytic decomposition of trifunctional carbene generating photoaffinity probes in methanolic solution was studied, a cleavage reaction with butylamine in water, the conjugation with a ligand (moenomycin), and experiments that demonstrate that the fully armed probes interact with penicillin-binding protein 1b. 

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