Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

@article{Hidaka1984IsoquinolinesulfonamidesNA,
  title={Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.},
  author={Hiroyoshi Hidaka and Masaki Inagaki and Sachiyo Kawamoto and Yasuharu Sasaki},
  journal={Biochemistry},
  year={1984},
  volume={23 21},
  pages={
          5036-41
        }
}
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit protein kinases, and some of the derivatives exhibited selective inhibition toward a certain protein kinase. cAMP-dependent, cGMP-dependent, and Ca2+-phospholipid… 
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