Isoquinoline derivatives via stepwise regioselective sp(2) and sp(3) C-H bond functionalizations.

Abstract

Efficient and practically attractive stepwise ruthenium- and palladium-catalyzed regioselective C-H bond functionalizations were achieved to produce 4-substituted tetrahydroisoquinoline derivatives featuring various heteroaromatic substructures in moderate to good yields. Both ruthenium- and palladium-based catalytic processes generated nontoxic and easily separable side products.

DOI: 10.1021/jo300237s

Cite this paper

@article{Boudiar2012IsoquinolineDV, title={Isoquinoline derivatives via stepwise regioselective sp(2) and sp(3) C-H bond functionalizations.}, author={Tarek Boudiar and Zeyneb Sahli and Basker Sundararaju and Mathieu Achard and Zahia Kabouche and Henri Doucet and Christian Bruneau}, journal={The Journal of organic chemistry}, year={2012}, volume={77 7}, pages={3674-8} }