Isoproterenol stimulates 5'-AMP-activated protein kinase and fatty acid oxidation in neonatal hearts.

@article{Jaswal2010IsoproterenolS5,
  title={Isoproterenol stimulates 5'-AMP-activated protein kinase and fatty acid oxidation in neonatal hearts.},
  author={Jagdip S. Jaswal and Chad R Lund and Wendy Keung and Donna L. Beker and Ivan M. Rebeyka and Gary D Lopaschuk},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 4},
  pages={H1135-45}
}
Isoproterenol increases phosphorylation of LKB, 5'-AMP-activated protein kinase (AMPK), and acetyl-CoA carboxylase (ACC), enzymes involved in regulating fatty acid oxidation. However, inotropic stimulation selectively increases glucose oxidation in adult hearts. In the neonatal heart, fatty acid oxidation becomes a major energy source, while glucose oxidation remains low. This study tested the hypothesis that increased energy demand imposed by isoproterenol originates from fatty acid oxidation… CONTINUE READING
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