Isoproterenol inhibits bacterial lipopolysaccharide-stimulated release of tumor necrosis factor-alpha from human heart tissue.

@article{Smart2000IsoproterenolIB,
  title={Isoproterenol inhibits bacterial lipopolysaccharide-stimulated release of tumor necrosis factor-alpha from human heart tissue.},
  author={Kathryn Smart and D J Warejcka and Manuel R. Castresana and Martin L. Dalton and Jerry G Webb and Walter H Newman},
  journal={The American surgeon},
  year={2000},
  volume={66 10},
  pages={947-51}
}
Recent evidence suggests that inflammatory cytokines, particularly tumor necrosis factor alpha (TNF-alpha), may play a role in heart disease. Elevated plasma levels of the cytokine have been reported in congestive heart failure and severe angina and after myocardial infarction. The exact role of TNF-alpha in heart disease and how production is stimulated and regulated in the heart are current areas of investigation. Regarding regulation of production, isoproterenol elevates cyclic AMP and… CONTINUE READING