Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis.

  title={Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis.},
  author={Ivor J. Benjamin and Jorge E. Jalil and L. B. Tan and K Cho and Karl T. Weber and William A. Clark},
  journal={Circulation research},
  volume={65 3},
Treatment of rats with the beta-adrenergic agonist isoproterenol results in cardiac hypertrophy, myocyte necrosis, and interstitial cell fibrosis. Our objectives in this study have been to examine whether hypertrophy and fibrosis occur in a compensatory and reparative response to myocyte loss or whether either process may be occurring independently of… CONTINUE READING