Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion.

@article{Donahoo1997IsoproterenolAS,
  title={Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion.},
  author={William Troy Donahoo and Dalan R. Jensen and Tracey Yost and Robert H Eckel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1997},
  volume={82 12},
  pages={4139-43}
}
In cultured adipocytes, leptin is increased by insulin and decreased by cAMP. In animal models, insulin and agents that increase intracellular cAMP have been shown to similarly affect plasma leptin in vivo. This study was undertaken to test the hypothesis that in humans increased cAMP induced by isoproterenol would decrease leptin. Five groups of normal weight subjects were studied; 1) subjects infused with isoproterenol at a rate of 24 ng/kg/min (ISO24); 2) subjects infused with isoproterenol… CONTINUE READING

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