Isoproterenol Cytotoxicity is Dependent on the Differentiation State of the Cardiomyoblast H9c2 Cell Line

@article{Branco2011IsoproterenolCI,
  title={Isoproterenol Cytotoxicity is Dependent on the Differentiation State of the Cardiomyoblast H9c2 Cell Line},
  author={Ana F. Branco and Sandro L. Pereira and Ana C Moreira and Jon M. Holy and Vilma A. Sard{\~a}o and Paulo J. Oliveira},
  journal={Cardiovascular Toxicology},
  year={2011},
  volume={11},
  pages={191-203}
}
H9c2 cells are used as a surrogate for cardiac cells in several toxicological studies, which are usually performed with cells in their undifferentiated state, raising questions on the applicability of the results to adult cardiomyocytes. Since H9c2 myoblasts have the capacity to differentiate into skeletal and cardiac muscle cells under different conditions, the hypothesis of the present work was that cells in different differentiation states differ in their susceptibility to toxicants. In… CONTINUE READING
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