Isoprostanes and other markers of peroxidation in atherosclerosis.

  title={Isoprostanes and other markers of peroxidation in atherosclerosis.},
  author={Paola Patrignani and Stefania Tacconelli},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  volume={10 Suppl 1},
Several lines of evidence suggest that reactive oxygen species play a role in the development of vasculopathies, including those that define atherosclerosis, hypertension and restenosis after angioplasty. Confused picture emerging from prospective clinical trials of anti-oxidants may reflect inadequacy of traditional indices of lipid peroxidation in the recruitment of appropriate patients and in guiding the selection of the appropriate dose of anti-oxidant to be tested. Ex vivo indices of… CONTINUE READING