Isoprostane levels in urine of preterm newborns treated with ibuprofen for patent ductus arteriosus closure

@article{Longini2010IsoprostaneLI,
  title={Isoprostane levels in urine of preterm newborns treated with ibuprofen for patent ductus arteriosus closure},
  author={Mariangela Longini and Serafina Perrone and Piero Vezzosi and Fabrizio Proietti and Barbara Marzocchi and Giuseppe Buonocore and Vassilios Fanos and Roberto Antonucci and Enrico M Brunoldi},
  journal={Pediatric Nephrology},
  year={2010},
  volume={26},
  pages={105-109}
}
Patent ductus arteriosus (PDA) is the most common cardiovascular abnormality of the preterm infant usually treated with ibuprofen (IBU). PDA is strictly related to oxidative stress (OS) in neonates. This study tests the hypothesis that OS occurs in neonates with PDA and that IBU treatment reduces OS. Forty-three preterm babies with gestational age (GA) <33 weeks were studied prospectively. Three urine samples were collected: at time 0 (before starting treatment), time 1 (after pharmacological… CONTINUE READING

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