Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization.

@article{Didsbury1990IsoprenylationOT,
  title={Isoprenylation of the low molecular mass GTP-binding proteins rac 1 and rac 2: possible role in membrane localization.},
  author={John R. Didsbury and R. J. Uhing and Ralph Snyderman},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={171 2},
  pages={804-12}
}
Ras proteins can be modified at their COOH-terminal cysteine in the motif Cys-Ali-Ali-Xaa by a farnesyl isoprenoid. This modification is essential for membrane association and biological activity of ras proteins. A similar COOH-terminal amino acid sequence, Cys-Xaa-Ali-Xaa, exists in the ras-related GTP-binding proteins rac 1 and rac 2. To determine whether… CONTINUE READING