Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway.

@article{Stamatakis2002IsoprenylationOR,
  title={Isoprenylation of RhoB is necessary for its degradation. A novel determinant in the complex regulation of RhoB expression by the mevalonate pathway.},
  author={Konstantinos Stamatakis and Eva Cernuda-Moroll{\'o}n and Octavio Hern{\'a}ndez-Perera and Dolores P{\'e}rez-Sala},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 51},
  pages={49389-96}
}
Statins improve vascular functions by mechanisms independent from their cholesterol-lowering effect. Rho GTPases are emerging as key targets for the vascular effects of statins. RhoB is a short-lived, early-response inducible protein involved in receptor endocytosis, apoptosis, and gene expression. Here we show that statins regulate RhoB expression by… CONTINUE READING