Isoprenylation Is Required for the Processing of The Lamin A Precursor

  • Published 2002

Abstract

The nuclear lamina proteins, prelamin A, lamin B, and a 70-kD lamina-associated protein, are posttranslationally modified by a metabolite derived from mevalonate. This modification can be inhibited by treatment with (3-R,S)-3-fluoromevalonate, demonstrating that it is isoprenoid in nature. We have examined the association between isoprenoid metabolism and… (More)

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Cite this paper

@inproceedings{2002IsoprenylationIR, title={Isoprenylation Is Required for the Processing of The Lamin A Precursor}, author={}, year={2002} }