Isoprenoids control germ cell migration downstream of HMGCoA reductase.

Abstract

3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAr) provides attractive cues to Drosophila germ cells, guiding them toward the embryonic gonad. However, it remains unclear how HMGCoAr mediates this attraction. In a genomic analysis of the HMGCoAr pathway, we found that the fly genome lacks several enzymes required for cholesterol biosynthesis, ruling… (More)

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Cite this paper

@article{Santos2004IsoprenoidsCG, title={Isoprenoids control germ cell migration downstream of HMGCoA reductase.}, author={Ana Cristina Santos and Ruth Lehmann}, journal={Developmental cell}, year={2004}, volume={6 2}, pages={283-93} }