Isoprenoid biosynthesis in multiple sclerosis, II. A possible role of NADPH.

@article{Steen1987IsoprenoidBI,
  title={Isoprenoid biosynthesis in multiple sclerosis, II. A possible role of NADPH.},
  author={Gerard Steen and H. Axelsson and M Bowallius and N Holthuis and B M Molander},
  journal={Acta neurologica Scandinavica},
  year={1987},
  volume={76 6},
  pages={461-7}
}
Genetic predisposition in MS, influence of fat consumption on the disease, and excretion of lipid metabolites in urine led us to investigate isoprenoid metabolism in this disease. Ubiquinone concentration and biosynthesis was normal in lymphocytes. Cytochrome oxidase, which contains an isoprenoid side chain, was normal in activity. Cholesterol biosynthesis from acetate was found to be elevated in MS, and so was triglyceride biosynthesis. Increased biosynthesis may offer a very simple… CONTINUE READING
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