Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.

@article{Kuntz2005IsoprenoidBA,
  title={Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.},
  author={Lionel Kuntz and Denis Tritsch and Catherine Grosdemange-Billiard and Andr{\'e}a Hemmerlin and Audrey Willem and Thomas J. Bach and Michel Rohmer},
  journal={The Biochemical journal},
  year={2005},
  volume={386 Pt 1},
  pages={
          127-35
        }
}
Isoprenoid biosynthesis via the methylerythritol phosphate pathway is a target against pathogenic bacteria and the malaria parasite Plasmodium falciparum. 4-(Hydroxyamino)-4-oxobutylphosphonic acid and 4-[hydroxy(methyl)amino]-4-oxobutyl phosphonic acid, two novel inhibitors of DXR (1-deoxy-D-xylulose 5-phosphate reducto-isomerase), the second enzyme of the pathway, have been synthesized and compared with fosmidomycin, the best known inhibitor of this enzyme. The latter phosphonohydroxamic acid… CONTINUE READING

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