Corpus ID: 20160027

Isoprenoid biosynthesis as a novel target for antibacterial and antiparasitic drugs.

@article{Rohmer2004IsoprenoidBA,
  title={Isoprenoid biosynthesis as a novel target for antibacterial and antiparasitic drugs.},
  author={Michel. Rohmer and Catherine Grosdemange-Billiard and Myriam Seemann and Denis Tritsch},
  journal={Current opinion in investigational drugs},
  year={2004},
  volume={5 2},
  pages={
          154-62
        }
}
The mevalonate-independent methylerythritol phosphate pathway is a long overlooked metabolic pathway for isoprenoid biosynthesis. It is present in most bacteria, including pathogens and opportunistic pathogens, in some unicellular eukaryotes, including the parasite responsible for malaria, and in the chloroplasts of all phototrophic organisms. It represents an alternative to the mevalonate pathway, which is only present in animals, fungi, the plant cytoplasm, archaebacteria and some eubacteria… Expand
Isoprenoid biosynthetic pathways as anti-infective drug targets.
TLDR
The genes, enzymes, intermediates and mechanisms of the biosynthetic route have been elucidated by a combination of comparative genomics, enzymology, advanced NMR technology and crystallography and the results provide the basis for the development of novel anti-infective drugs. Expand
Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.
TLDR
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TLDR
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Current Therapeutics, Their Problems, and Sulfur-Containing-Amino-Acid Metabolism as a Novel Target against Infections by “Amitochondriate” Protozoan Parasites
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TLDR
A 2-D Fluorescence Difference Gel Electrophoresis proteomic approach has been applied to identify defense responses in E. coli cells being shortly exposed to fosmidomycin, and it seems that combined strategies are promptly induced. Expand
From Molecular Fossils of Bacterial Hopanoids to the Formation of Isoprene Units: Discovery and Elucidation of the Methylerythritol Phosphate Pathway
TLDR
The key steps of the discovery and elucidation of this metabolic route are presented in this review and it is shown that Methylerythritol phosphate, already presenting the C5 branched isoprene skeleton, is the key intermediate. Expand
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A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
TLDR
It can be concluded that in angiosperms, under standard growth conditions, C₂₀-phytyl moieties, C ₃₄-triterpenes and Cℓ-carotenoids are made nearly exclusively within compartmentalized pathways, while mixed origins are widespread for other types of isoprenoid-derived molecules. Expand
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A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria and the presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprene biosynthesis in P. falcIParum depends on the DOXP pathway. Expand
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2C-Methyl-D-erythritol was shown to be a putative intermediate in the biosynthetic pathway leading to isopentenyl diphosphate, which potentially represents a novel target for antibacterial drugs and herbicides. Expand
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TLDR
The mechanism of action of fosmidomycin (FR-31564), a phosphonic acid containing antibiotic, was examined against Escherichia coli, Micrococcus luteus and other bacteria, suggesting that inhibition of the biosynthesis of a common precursor of these isoprenoids might be the main site of its antibacterial activity. Expand
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