Isoprenoid Biosynthesis in Rat Liver Peroxisomes

  • Johan EricssonSQ, Eeva-Liisa Appelkvistll, Anders ThelinS, Tadeusz Chojnackill, Gustav DallnerSlI
  • Published 2001

Abstract

peroxisomes were able to utilize [’HlisopenIsolated tenyl diphosphate to synthesize farnesyl diphosphate, which then was utilized as substrate by both the peroxisomal squalene synthetase and cis-prenyltransferase. The specific activity of squalene synthetase in peroxisomes was as high as in microsomes, i.e. 160 pmol/mg of protein/min. If NADPH was omitted… (More)

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