Isoprenaline-induced increase in mRNA levels of inhibitory G-protein α-subunits in rat heart

@article{Eschenhagen2004IsoprenalineinducedII,
  title={Isoprenaline-induced increase in mRNA levels of inhibitory G-protein α-subunits in rat heart},
  author={Thomas Eschenhagen and Ulrike Mende and Monika Nose and W. Schmitz and Hasso Scholz and Ascan Warnholtz and Jens-Michael Wiistel},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={343},
  pages={609-615}
}
Long-term β-adrenergic stimulation has been shown to desensitize the β-adrenoceptor/adenylyl cyclase signalling pathway at both the receptor and the G-protein level. To further elucidate the cellular mechanism of G-protein regulation we investigated the influence of prolonged infusion of isoprenaline (2.4 mg/kg·d) on myocardial mRNA levels of different G-protein α-subunits in rats. For comparison rats were treated with triiodothyronine (T3; 0.5 mg/kg·d) which induces cardiac hypertrophy like… CONTINUE READING