Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes.

@article{AlegreCebollada2010IsopeptideBB,
  title={Isopeptide bonds block the mechanical extension of pili in pathogenic Streptococcus pyogenes.},
  author={Jorge Alegre-Cebollada and Carmen L. Badilla and J. M. Fern{\'a}ndez},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 15},
  pages={
          11235-42
        }
}
In the early stages of an infection, pathogenic bacteria use long fibrous structures known as pili as adhesive anchors for attachment to the host cells. These structures also play key roles in colony and biofilm formation. In all those processes, pili must withstand large mechanical forces. The pili of the nasty gram-positive human pathogen Streptococcus pyogenes are assembled as single, micrometer long tandem modular proteins of covalently linked repeats of pilin proteins. Here we use single… CONTINUE READING

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Mechanical Characterization of a Gram-positive Major Pilin 11242 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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