Isopentenyl pyrophosphate secreted from Zoledronate-stimulated myeloma cells, activates the chemotaxis of γδT cells.

@article{Ashihara2015IsopentenylPS,
  title={Isopentenyl pyrophosphate secreted from Zoledronate-stimulated myeloma cells, activates the chemotaxis of γδT cells.},
  author={Eishi Ashihara and Tatsuya Munaka and Shinya Kimura and Saori Nakagawa and Yoko Nakagawa and Masaki Kanai and Hideyo Hirai and Hirohisa Abe and Takashi Miida and Susumu Yamato and Shuichi Shoji and Taira Maekawa},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={463 4},
  pages={650-5}
}
γδT cell receptor (TCR)-positive T cells, which control the innate immune system, display anti-tumor immunity as well as other non-immune-mediated anti-cancer effects. γδT cells expanded ex vivo by nitrogen-containing bisphosphonate (N-BP) treatment can kill tumor cells. N-BP inhibits farnesyl pyrophosphate synthase in the mevalonate pathway, resulting in… CONTINUE READING