Isoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5.

Abstract

Hepatoma cells are relatively resistant to TRAIL. We have previously shown that isoobtusilactone A (IOA), a potent anticancer agent isolated from Cinnamomum kotoense, induced mitochondria-mediated apoptosis in hepatoma cells. Here, we report that IOA could potentiate TRAIL-induced apoptosis in Hep G2 cells. The combined treatment with IOA and TRAIL… (More)
DOI: 10.1021/jf2051224

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@article{Chen2012IsoobtusilactoneAS, title={Isoobtusilactone A sensitizes human hepatoma Hep G2 cells to TRAIL-induced apoptosis via ROS and CHOP-mediated up-regulation of DR5.}, author={Chung-Yi Chen and S L Yiin and Jue-Liang Hsu and Wei-Che Wang and Shan-Chun Lin and C J Chern}, journal={Journal of agricultural and food chemistry}, year={2012}, volume={60 13}, pages={3533-9} }