Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.

@article{McClure2012IsonicotinamideES,
  title={Isonicotinamide enhances Sir2 protein-mediated silencing and longevity in yeast by raising intracellular NAD+ concentration.},
  author={Julie M. McClure and Margaret B. Wierman and Nazif Maqani and Jeffrey S Smith},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 25},
  pages={20957-66}
}
Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein deacetylases that function in the regulation of gene transcription, cellular metabolism, and aging. Their activity requires the maintenance of an adequate intracellular NAD(+) concentration through the combined action of NAD(+) biosynthesis and salvage pathways. Nicotinamide (NAM) is a key NAD(+) precursor that is also a byproduct and feedback inhibitor of the deacetylation reaction. In Saccharomyces cerevisiae, the… CONTINUE READING
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