Isoniazid resistance of exponentially growing Mycobacterium smegmatis biofilm culture.

@article{Teng2003IsoniazidRO,
  title={Isoniazid resistance of exponentially growing Mycobacterium smegmatis biofilm culture.},
  author={Raymond M.H. Teng and Thomas P. Dick},
  journal={FEMS microbiology letters},
  year={2003},
  volume={227 2},
  pages={
          171-4
        }
}
  • Raymond M.H. Teng, Thomas P. Dick
  • Published in FEMS microbiology letters 2003
  • Biology, Medicine
  • Biofilm growth of Mycobacterium smegmatis was found to be unaffected at an isoniazid concentration that inhibited growth of planktonic bacilli (i.e. at isoniazid minimum inhibitory concentration=10 microg ml(-1)). Significant growth (50% of drug-free control) of biofilms was observed at up to 40 microg ml(-1) and the MIC for biofilm growth showed an increase to up to 80 microg ml(-1) isoniazid. Thus, the biofilm growth modus appears to be a strategy for replicating bacilli to evade the… CONTINUE READING

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