Isoniazid prophylaxis against tuberculosis in children.

To the Editor: The results of the study by Madhi et al. (July 7 issue)1 contradict those of a study in which isoniazid prophylaxis reduced mortality and the incidence of tuberculosis by 54% and 79%, respectively,2 in children infected with the human immunodeficiency virus (HIV). The authors suggest that the findings reported in the 2007 study may have… CONTINUE READING