Isoniazid preventive therapy for tuberculosis in HIV-1-infected adults: results of a randomized controlled trial.

@article{Hawken1997IsoniazidPT,
  title={Isoniazid preventive therapy for tuberculosis in HIV-1-infected adults: results of a randomized controlled trial.},
  author={Mark P. Hawken and Helen K. Meme and Lindsay C C Elliott and Jeremiah Muhwa Chakaya and Jeffery S. Morris and Willie A. Githui and Ernest Juma and Joseph A Odhiambo and L N Thiong'o and J N Kimari and Elizabeth N. Ngugi and Job Joab Bwayo and Charles F. Gilks and Francis Allan Plummer and John D. H. Porter and Paul P Nunn and K W Mcadam},
  journal={AIDS},
  year={1997},
  volume={11 7},
  pages={875-82}
}
OBJECTIVES To determine the efficacy of isoniazid 300 mg daily for 6 months in the prevention of tuberculosis in HIV-1-infected adults and to determine whether tuberculosis preventive therapy prolongs survival in HIV-1-infected adults. DESIGN AND SETTING Randomized, double-blind, placebo-controlled trial in Nairobi, Kenya. SUBJECTS Six hundred and eighty-four HIV-1-infected adults. MAIN OUTCOME MEASURES Development of tuberculosis and death. RESULTS Three hundred and forty-two subjects… CONTINUE READING
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