Isoniazid hepatotoxicity associated with treatment of latent tuberculosis infection: a 7-year evaluation from a public health tuberculosis clinic.

@article{Fountain2005IsoniazidHA,
  title={Isoniazid hepatotoxicity associated with treatment of latent tuberculosis infection: a 7-year evaluation from a public health tuberculosis clinic.},
  author={Francis F Fountain and Elizabeth A. Tolley and Cary R Chrisman and Timothy H Self},
  journal={Chest},
  year={2005},
  volume={128 1},
  pages={116-23}
}
OBJECTIVES To determine the overall incidence of isoniazid (INH) hepatotoxicity in a public health tuberculosis clinic over a 7-year period, and to determine if systematic, limited aspartate aminotransferase (AST) monitoring would be of benefit in detecting INH hepatotoxicity. METHODS Evaluation of INH hepatotoxicity in adults aged > or = 25 years from a database maintained from fall 1996 to 2003 in a public health department clinic. Hepatotoxicity was defined as AST levels more than five… CONTINUE READING
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