Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase.

@article{Fleming1999IsometricCI,
  title={Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase.},
  author={Ingrid Fleming and Johann Bauersachs and Arnd Schaefer and Dimitri Scholz and Jan Aldershvile and R. S. Busse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 3},
  pages={1123-8}
}
Shear stress and tyrosine phosphatase inhibitors have been shown to activate the endothelial NO synthase (eNOS) in a Ca2+/calmodulin-independent manner. We report here that isometric contraction of rabbit aorta activates eNOS by a pharmacologically identical pathway. Endothelium-intact aortic rings were precontracted under isometric conditions up to 60% of the maximal phenylephrine-induced tone. The NO synthase inhibitor NGnitro-L-arginine (L-NA) and the soluble guanylyl cyclase inhibitor NS… CONTINUE READING
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