Isometric and dynamic contractile properties of porcine skinned cardiac myocytes after stunning.

@article{McDonald1995IsometricAD,
  title={Isometric and dynamic contractile properties of porcine skinned cardiac myocytes after stunning.},
  author={Kerry S McDonald and Pradeep Puthenveetil Abraham Mammen and K T Strang and Richard L Moss and Wayne P. Miller},
  journal={Circulation research},
  year={1995},
  volume={77 5},
  pages={964-72}
}
The purpose of this study was to investigate myofibrillar mechanisms of depressed contractile function associated with myocardial stunning. We first tested whether the degree of stunning was directly related to changes in myofilament Ca2+ sensitivity. Variable degrees and durations of low-flow ischemia were followed by 30 minutes of reperfusion in an open-chest porcine model of regional myocardial stunning (n = 27). Ca2+ sensitivity of isometric tension was measured in skinned myocytes obtained… CONTINUE READING

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