Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins.

@article{McBee2000IsomerizationOA,
  title={Isomerization of all-trans-retinol to cis-retinols in bovine retinal pigment epithelial cells: dependence on the specificity of retinoid-binding proteins.},
  author={Joshua K. McBee and Vladimir Kuksa and Rosana {\'A}lvarez and {\'A}ngel R de Lera and Oleg V Prezhdo and Françoise Haeseleer and Izabela Sokal and Krzysztof Palczewski},
  journal={Biochemistry},
  year={2000},
  volume={39 37},
  pages={11370-80}
}
In the retinal rod and cone photoreceptors, light photoactivates rhodopsin or cone visual pigments by converting 11-cis-retinal to all-trans-retinal, the process that ultimately results in phototransduction and visual sensation. The production of 11-cis-retinal in adjacent retinal pigment epithelial (RPE) cells is a fundamental process that allows regeneration of the vertebrate visual system. Here, we present evidence that all-trans-retinol is unstable in the presence of H(+) and rearranges to… CONTINUE READING